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What does “Mary Jane” mean?
A play on words deriving from a literal translation of the Spanish word “marijuana.” It's a common nickname for weed, and it especially became popular due to Rick James' 1978 hit of the same title, in which he proclaims to be in love with a woman (aptly called Mary Jane) who always knows how to make him feel better. As the song says, cannabis can be used to relieve depression and anxiety symptoms, and it's also perfect for when you just want a nice, relaxing time.
Example usage for Mary Jane
Sorry, I can't go out tonight. I've got a date with Mary Jane.